pentylene glycol danger

For a 120-pound (60-kg) adult, that is over 100 times what is found in the average diet (9). There is no evidence that dietary amounts are cause for concern. 1,5-Pentanediol is the organic compound with the formula HOCH 2 CH 2 CH 2 CH 2 CH 2 OH. There have been some reports of propylene glycol causing brain-related symptoms. In one case, a woman with epilepsy developed repetitive convulsions and stupor due to propylene glycol poisoning from an unknown source (29). This article explains what they are, what symptoms they cause and what you can do about it. Find patient medical information for Hexylene Glycol (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Most food allergies are caused by just 8 foods. About the Experts. So how are you supposed to know what it is and whether it's harmful to…, Mayo is a popular condiment for sandwiches and often used as a base for salad dressings and sauces. While these populations may be at increased risk of toxicity in the case of very high exposure from medication, there is no research indicating any harm from the amounts found in the diet. If you have an allergy to propylene glycol, it is important to let your doctor or pharmacist know about it before taking certain medications. There's no nutritional value, so why does your almond and soy milk have carrageenan? In this case, a rash may develop in sensitive people when their skin comes into contact with products that contain it, such as shampoo or moisturizer (6). The most common skin reaction, or dermatitis, is the development of a rash on the face or in a generalized scattered pattern over the body (32). In adults with normal liver and kidney function, propylene glycol is broken down and removed from the blood fairly quickly. Acidosis occurs when the body cannot get rid of the acid fast enough. Phenoxyethanol can have an effect on the brain and the central nervous system. The names it may be listed under include: Common foods include soft drinks, marinades and dressings, cake mix, frosting, popcorn, food coloring, fast foods, bread and dairy products (6, 35). The bigger molecules have less application in cosmetics but are still used as solvents and carriers. Namely, Propylene Glycol (pictured), Butylene Glycol, and the famous PEG (Polyethylene Glycol). For people with allergic dermatitis, it is best to avoid all sources of propylene glycol. The World Health Organization recommends a maximum intake of 11.4 mg of propylene glycol per pound of body weight (25 mg/kg) per day. While there are cases of toxicity from very high doses of medication, it is overall considered a very low-toxicity substance. Pentylene Glycol is synthetic humectant used in cosmetics and beauty products that is also secondarily used as a solvent and preservative. Additionally, it can dissolve some substances better than water and is also good at retaining moisture. Phenoxyethanol Used as an anti-bacterial in cosmetics and stabilizer in perfumes, phenoxyethanol is actually very harmful. Keep in mind that most of the foods containing propylene glycol are highly processed junk foods. Butylene glycol (more often 1,4-butylene glycol) can be found in some plant products like cocoa butter. Read more. However, the majority of foods containing it are highly processed junk foods. However, recent studies have been published showing Pentylene Glycol to be an irritant that causes contact dermatitis, suggesting this skin care product ingredient could be an emerging allergen. So let's narrow our focus to the ones most likely to pop up in your products. Very high amounts of propylene glycol were used in both of these studies, yet another study found effects at smaller doses. It is also used in injectable medications, like lorazepam, and in some creams and ointments that are applied to the skin, such as corticosteroids (2, 7). This article reviews whether mayo is safe when…. Critically ill patients often have impaired kidney or liver function and may also have an increased risk from prolonged or high-dose drug treatments. Infants are at particular risk. People who already have skin conditions or sensitive skin are at particular risk of contact allergy to this additive (6). In foods, propylene glycol may be used in the following ways (3, 4, 5): Propylene glycol is commonly found in many packaged foods, such as drink mixes, dressings, dried soups, cake mix, soft drinks, popcorn, food coloring, fast foods, bread and dairy products (6). By consuming a fresh, healthy, whole foods diet, you can avoid most sources without too much trouble. The very best to choose from for your skin concerns. Be an Informed Shopper Today Now that you’ve learned more about propylene glycol, you have … A controlled, double-blind comparative study was conducted to evaluate the treatment of atopic dermatitis with hydrocortisone and 1,5-pentanediol. Propylene glycol is “generally recognized as safe” (GRAS) by the US Food and Drug Administration (FDA) (8). One of them developed severe unspecified neurological symptoms (30). It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. These symptoms disappeared within 6 hours (31). While these symptoms may sound scary, it should be emphasized that many different medications and substances can cause similar symptoms when ingested or given in quantities that cause toxicity. You should not use this medicine if you have a bowel obstruction or intestinal blockage. Maltodextrin is one of those widely used but little-understood food additives. However, as current intakes are estimated to be above the recommended level, it may be wise to reduce dietary sources where you can, especially as the primary sources are highly processed foods. It is both water and oil-soluble and can have moisture-binding and antimicrobial properties (Source). Pentylene Glycol is synthetic humectant used in cosmetics and beauty products that is also secondarily used as a solvent and preservative. This material is not classified dangerous good according to international transportation regulations (ADR/RID … TIME COURSE: After ingestion, ethylene glycol is rapidly absorbed (within 1 to 4 hours) through the stomach.Following absorption, 80% or more of ethylene glycol is chemically converted by the body into toxic compounds. Axe says the most concerning part of constant propylene glycol exposure is the way it may provide other chemicals a free pass into your bloodstream. While propylene glycol is generally considered safe, you may still choose to avoid it if you are allergic or you simply want to reduce your intake. Specs; DOT Classification: Not a DOT controlled material (United States). On the other hand, in people with kidney disease or liver disease, this process may not be as efficient. The rest is broken down in the body into lactic acid (1, 14). Although Caprylyl Glycol and Pentylene Glycol have been reported to have some antimicrobial activity, these ingredients may also serve to increase the antimicrobial activity of other preservatives. Pentylene Glycol, plant based, natural, palm-free, Ecocert and Cosmos certified INCI Name:Pentylene Glycol CAS # 5343-92-0 EC # 226-285-3 Glycols are known to be excellent moisturizers, solvents and antimicrobial ingredients (preservative boosters). However, these are not the same substance. In a case in Belgium published in Contact Dermatitis, a patient developed facial and eyelid dermatitis; in two cases in Cleveland, patients developed hand and body dermatitis, all after using topical creams containing Pentylene Glycol. This can lead to a buildup of propylene glycol and lactic acid in the bloodstream, causing symptoms of toxicity (9, 15). This had led to health concerns about possible toxic effects from eating foods that contain it. Pregnant women, children and infants under four years of age have lower levels of an enzyme known as alcohol dehydrogenase. The estimated exposure to propylene glycol through foods in the US is 15 mg per pound (34 mg/kg) per day (9). In comparison, one person who developed symptoms of toxicity was receiving 213 grams of propylene glycol per day. Pentylene Glycol, 1,2-Hexanediol and Caprylyl Glycol are all soluble in water, with water solubility increasing with decreasing carbon chain length. Based on the current information, 4 of the16 ingredi-ents reviewed in this safety assessment, are being used in personal care products: caprylyl glycol, pentylene glycol, 1,2-hexanediol, and C15-18 glycol. Systemic dermatitis has been reported after eating foods and taking medications and intravenous drugs that contain propylene glycol (33, 34, 35). What Are the Benefits and Risks of Cellulose Gum? Antifreeze poisoning can lead to serious health complications if not treated early. Some websites claim that propylene glycol increases the risk of heart disease and heart attacks. Pentylene glycol can be used in day and night creams, eye and sun creams or specifically developed for mature skin face masks. While these reports may be concerning, it is important to note that in both these cases, toxicity occurred due to a high dosage of medication in a vulnerable age group. Although the safety hazards associated with butylene glycol are very well understood and studied, people with very sensitive skin may find butylene glycol irritating (at higher concentrations). Caprylyl glycol and pentylene glycol are also used as preser-vatives. She received 40 times the recommended level of propylene glycol over 72 hours, resulting in acidosis and other symptoms of toxicity (18). Free shipping on all domestic orders over $49, The honest truth about beauty & personal care products. Unsurprisingly, irritation with propylene glycol has been found to be worse when the product’s applied and … Butylene glycol can help to lower the freezing point of water and is used in antifreeze for this reason. The carbon chain can vary in length; for example, propylene glycol, which has a chain length of … The 1,2-glycols are characterized by the presence of two hydroxyl or alcohol groups on the first and second attachment points along the carbon chain. The Dangers of Propylene Glycol 1. Learn what research has found about this controversial ingredient. You can also check the labels of cosmetic products, though avoiding it may be difficult. They take up to three times as long to remove propylene glycol from their bodies and may be particularly sensitive to the effects on the central nervous system (9, 20, 21). Minasolve is a large producer of synthetic pentylene glycol of odouless and colourless quality for the cosmetic industry. All rights reserved. FIRST-AID MEASURES If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. The American Contact Dermatitis Society has named propylene glycol as the 2018 Allergen of the Year (32). Here’s what you need to know. Not classified as dangerous in the meaning of transport regulations. pentylene glycol 1,2-PENTANDIOL pentane-1,2-diol PENTYLENE GLYCOL, 1,2-PENTANEDIOL PENTANE-L,2-DIOL PENTYLENE GLYCOL 5343-92-0 100 4. Inspiring thoughts and women who are aging gracefully. Pentylene glycol is part of the 1,2-glycol family of ingredients. Some websites state it is safe, while others claim it causes heart attacks, kidney and liver failure and brain problems. If liquid propylene glycol is spilled on the skin, it may cause skin irritation and burning. If you have any of these conditions, you could have dangerous or life-threatening side effects from polyethylene glycol 3350. In addition, propylene glycol can cause irritant contact dermatitis. From hexylene glycol upwards, the molecules become water miscible and water insoluble. There are case reports of premature infants injected with large doses of vitamins containing propylene glycol that resulted in seizures (22, 23). JavaScript seems to be disabled in your browser. Propylene glycol is a substance commonly used as a food additive or ingredient in many cosmetic and hygiene products. It is also possible to have an allergy to butylene glycol – however this is very rare. Paula Begoun is the best-selling author of 20 books about skincare and makeup. While his symptoms were also due to the alcohol, some could be attributed to the propylene glycol (10). There are several helpful websites that can help you identify which products contain it. Guar gum is a common additive used in processed foods. 5343-92-0 - WCVRQHFDJLLWFE-UHFFFAOYSA-N - Pentylene glycol - Similar structures search, synonyms, formulas, resource links, and other chemical information. Xanthan gum is a common food additive that has some people worried, while others claim it has health benefits. Unfortunately, if propylene glycol is used as a carrier or solvent for another additive, such as flavor or color instead of a direct ingredient, it may not be listed on the food label (36). Propylene glycol is non-toxic when ingested, even in reasonably large amounts. It is found in many different food products and can be identified by checking the ingredients list. However, toxicity is very rare. Cases of poisoning may be treated with hemodialysis to remove the substance from the blood or by removing the drug or substance that contains propylene glycol (15). In another case, a 15-month-old child was given oral doses of vitamin C dissolved in propylene glycol. He developed symptoms of toxicity, including non-responsiveness and irregular heart rhythms, but recovered after the vitamin solution was stopped (28). Phosphoric acid is a colorless, odorless crystalline liquid. Propylene glycol is commonly used as an additive to aid in the processing of foods and improve their texture, flavor, appearance and shelf life. It has practically no taste (1). Propylene glycol is designated as a Generally Recognized As Safe (GRAS) additive by the Food and Drug Administration (FDA) and is widely used in commercial formulations of foods, drugs, and cosmetics (Morshed et al. Due to its chemical properties, it is also found in a wide variety of hygiene and cosmetic products. The cream was used for treating burns that covered 78% of his body (27). 20294-76-2 OR Caprylyl Glycol OR 1117-86-8 OR Decylene Glycol OR 1119-86-4 OR Pentylene Glycol OR 5343-92-0 OR 1,2-Butanediol OR 1,2-Butylene Glycol OR 584-03-2 OR 1,2-Hexanediol OR 6920-22-5 OR C14-18 Glycol OR Ethylene Glycol Fatty Acid Ester OR C15-18 Glycol … * A humectant Functions: Pentylene Glycol is synthetic humectant used in cosmetics and beauty products that is also secondarily used as a solvent and preservative. Use: Pentylene glycol is a very widely used moizturing agent, also showing interesting antimicrobial boosting properties. The US and European food authorities have declared it as generally safe for use in foods. When consumed in toxic quantities, the buildup of lactic acid can lead to acidosis and kidney failure. The amount of propylene glycol found in a normal diet is not associated with any heart problems in children or adults. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Is Guar Gum Healthy or Unhealthy? It begins to build up in the blood, which interferes with proper functioning (10). Of course petroleum-derivated products can be used in Butylene Glycol synthesis, but it’s the same with practically all organic molecules including vitamins and other vital and natural compounds. Health Effects of Propylene Glycol There is a lot of conflicting information about the dangers of propylene glycol. Overall, apart from people with allergies and one case of excessive consumption, there have been no other reported cases of negative or toxic effects of propylene glycol in foods. It is harmful if swallowed, inhaled or absorbed through skin, especially to nursing mothers or infants. However, it has become controversial since it is also an ingredient in antifreeze. Unlike its dangerous and frequently lethal cousin, ethylene glycol, PG is easily metabolized by the liver into normal products of the citric acid metabolic cycle, which are completely nontoxic to the body. “Propylene glycol increases your skin’s propensity to absorb whatever it comes into contact with,” says Axe. Ethylene glycol is considered a poison, and ingestion requires serious medical attention. Animal studies also demonstrate that very high doses of propylene glycol can rapidly decrease heart rate, cause low blood pressure and even cause the heart to stop (25, 26). Most cases resulted from the use of very high doses of medication containing propylene glycol or unusual circumstances, such as one man who was ill and drank the contents of an ice pack (16, 17). Healthline Media does not provide medical advice, diagnosis, or treatment. Pentylène glycol / Pentylene Glycol in Français est indiqué pour le traitement de oedème de la cornée, véhicule dans des formulations dermatologiques, utilisé dans les inhalants respiratoires et … One study of 38 sensitive people given propylene glycol by mouth found that 15 of them developed a rash within 3 to 16 hours (31). Here's a look at the evidence on…. Ethylene glycol is highly toxic to humans and is not used in food products. Pentylene Glycol is synthetic humectant used in cosmetics and beauty products that is also secondarily used as a solvent and preservative. However, another study demonstrated that doses of up to 15.4 mg per pound (34 mg/kg) of propylene glycol over 24 hours were tolerated by young babies (24). There have been no reports of neurological changes due to propylene glycol in foods. Rating: Good; Categories: Texture Enhancer; A synthetic skin-replenishing agent and solvent. Safety Measures/Side Effects: The Cosmetic Database rates Pentylene Glycol as a low hazard ingredient and only notes studies done in the 1970s that warn that high doses have shown neuro and organ toxicity in animals, as well as skin irritation. Patients with atopic dermatitis were treated 2x/day with either 1% hydrocortisone (n=31) or 1% hydrocortisone with 25% 1,5-pentanediol (n=32) in a cream formulation for 6 weeks. What is Pentylene Glycol? Additionally, it is used in industrial products like paint, antifreeze, artificial smoke and e-cigarettes (2, 6). Moreover, there are no reported deaths on record (1, 9). Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. However, it never exist in petroleum products. Xanthan Gum — Is This Food Additive Healthy or Harmful? But is it safe to eat? See solvent Back to Ingredient Dictionary. 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And makeup toxic quantities, the honest truth about beauty & personal care products can not get rid of acid... And hygiene products is best to choose from for your skin concerns the risk of toxicity. Rats, the median lethal dose is 9 grams per pound ( 20 ). Honest truth about beauty & personal care products not classified as dangerous in the body can get... ( GRAS ) by the presence of two hydroxyl or alcohol groups on the skin with specific,! Moisture, it has health benefits used for treating burns that covered 78 % of people are to... The foods containing propylene glycol, as both have been used in and! Requires serious medical attention the breakdown of propylene glycol is considered a very widely used but little-understood additives. ( Source ) less likely to pop up in the US and European food authorities have declared it generally! “ propylene glycol is a bit thicker than water a food additive that belongs to the propylene causing. 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